Sixth International Conference on Spoken Language Processing
October 16-20, 2000
Brain Regions Responsible for Word Retrieval, Speech Production and Deficient Word Fluency in Elderly People: A PET Activation Study
Itaru F. Tatsumi (1), Michio Senda (2), Kenji Ishii (2), Masahiro Mishina (3), Masashi Oyama (3), Hinako Toyama (4), Keiichi Oda (2), Masayuki Tanaka (5), Yasuyuki Gondo (6)
(1) Language & Cognition, Tokyo Metropolitan Institute of Gerontology, Japan
A PET (positron emission tomography) activation study
using word-fluency tasks was administered to identify the
network for word retrieval and speech production, and to
explore mechanisms for word finding difficulty observed in
elderly people. It was found that the left anterior insula, as
opposed to Broca’s area, left premotor area, the anterior
cingulate gyrus, thalamus, basal ganglia, midbrain and
cerebellum constitute the network for speech production. In
semantic processing for word retrieval of proper names, the left
anterior temporal lobe and frontal pole (BA 10) were activated.
As for the animate and inanimate name retrieval, and the
syllable fluency the same areas, viz., the left inferoposterior
temporal lobe (BA 37) and left inferior frontal lobe (Broca’s
area), were activated.
(2) PET Center, Tokyo Metropolitan Institute of Gerontology, Japan
(3) Internal Medicine II, Nihon Medical School, Bunkyo-ku, Tokyo, Japan
(4) National Institute of Radiological Sciences, Chiba, Japan
(5) Primate Institute, University of Kyoto, Kanrin, Inuyama, Aichi, Japan
(6) Psychology, Tokyo Metropolitan Institute of Gerontology, Japan
In elderly people an activated area was generally small, and
those regions activated in young people were sometimes
inactive. However, an great, stable and diffuse activation was
also observed. The latter may reflect an effort to
compensate for deficient word retrieval. These are
possible sources of word finding difficulty in the elderly.
Tatsumi, Itaru F. / Senda, Michio / Ishii, Kenji / Mishina, Masahiro / Oyama, Masashi / Toyama, Hinako / Oda, Keiichi / Tanaka, Masayuki / Gondo, Yasuyuki (2000):
"Brain regions responsible for word retrieval, speech production and deficient word fluency in elderly people: a PET activation study",
In ICSLP-2000, vol.2, 5-10.