7th International Conference on Spoken Language Processing

September 16-20, 2002
Denver, Colorado, USA

Hypophonia in Parkinson Disease: Neural Correlates of Voice Treatment with LSVT Revealed by PET

Mario Liotti (1), Lorraine O. Ramig (2), Deanie Vogel (3), Pamela New3, Chris Cook (3), Peter Fox (3)

(1) University of Aberdeen, U.K.; (2) University of Colorado at Boulder, USA; (3) University of Texas Health Science Center at San Antonio, USA

This study investigated the neural correlates of hypophonia in individuals with Idiopathic Parkinsonís disease (IPD) before and after the Lee Silverman Voice Treatment (LSVT), using 15O-H2O Positron Emission Tomography (PET). Regional cerebral blood flow (rCBF) changes associated with overt speech-motor tasks relative to the resting state were measured in the IPD subjects before and after therapy, and in a group of healthy controls. Before LSVT, patients had strong speech- related activations in motor and premotor cortex, supplementary motor cortex and inferior lateral premotor cortex which were significantly reduced post-LSVT. In addition, significant right-sided activations were present in anterior insular cortex, caudate head, putamen, and dorsolateral prefrontal cortex following LSVT. Finally, the LSVT-induced neural changes were not present with transient experimenter-cued increases of loudness in LSVT-untreated patients. This treatment-dependant functional reorganization suggests a shift from an abnormally effortful to a more automatic implementation of speech-motor actions.

Full Paper

Bibliographic reference.  Liotti, Mario / Ramig, Lorraine O. / Vogel, Deanie / New3, Pamela / Cook, Chris / Fox, Peter (2002): "Hypophonia in parkinson disease: neural correlates of voice treatment with LSVT revealed by PET", In ICSLP-2002, 2477-2480.