Third International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications (MAVEBA 2003)

Florence, Italy
December 10-12, 2003

Spectral Entropy Signature of Speech Perturbation in Adult Acquired Growth Hormone Deficiency

C. J. Moore (1), Kathiresan Manickam (1), S. Shalet (2), T. Willard (3), S. Jones (4)

(1) North Western Medical Physics, Christie Hospital, Manchester, UK
(2) Department of Endocrinology, Christie Hospital, Manchester, UK
(3) North Western Medical Physics, Withington Hospital, Manchester, UK
(4) Department of Speech and Language Therapy, Wythenshawe Hospital, Manchester, UK

Approximate entropy (ApEn) adapted to quantify the pattern complexity across the electroglottogram (EGG) spectral domain characterizes normal male vowel phonation in two groups, a majority group (G1) with high ApEn and a minority group (G2) with low ApEn. Using the ApEn measure of normality a sample of post-treatment male oncology patients with adult onset growth hormone deficiency (GHD) shows distinctive spectral entropy signatures. These are consistent with either disrupted larynx development in relative youth, with high normal-group G1 complexity and elevated pitch, or loss of conscious control in middle age, with low normal group G2 or worse complexity. This is at least initial evidence that speech perturbation may be of value in detecting the adult GHD in oncology.

Index Terms. Speech, Complexity, Endocrine, Disruption, Oncology

Full Paper (reprinted with permission from Firenze University Press)

Bibliographic reference.  Moore, C. J. / Manickam, Kathiresan / Shalet, S. / Willard, T. / Jones, S. (2003): "Spectral entropy signature of speech perturbation in adult acquired growth hormone deficiency", In MAVEBA-2003, 255-258.